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KMID : 0364819870250040353
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Korean Journal of Microbiology
1987 Volume.25 No. 4 p.353 ~ p.359
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Regulation of Tylosin Biosynthesis by Cell Growth Rate in Streptomyces fradiae
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Kang, Hyun Ah/강현아
Lee, Jeong Hyun/Lee, Kye Joon/이정현/이계준
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Abstract
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1
The aim of the present study was to investigate the effects of growth rate on the biosynthesis of tylosin in Streptomyces fradiae. In order to duddate the relation between the growth rate sad the tylosiu formation rate, the activities of enzymes involved in oxaloaeetate metabolism were deteraised using cells grown at different growth rates in dsemostats. As the results, it was found that the specific rate of tyfoaia foraatlon(q,) was closely related to the specific cell growth rate an4the maximum value of qp was 1.1mg tylosia, g-1 cell, h-1 at the growth rate 0.0131-1. However farther increase b the growth rate over 0.013h-1 resulted in apparent decrease of q,. The synthesis and activities of citrate syathase, aspartate aminotransferase, and PEP carbosylase were very low at lower growth rate. On the other hand, the activity and synthesis of methylaabayi-CoA csrboxyttraasferase was closely related to tylosin formation. Therefore it was concluded that tylosin formation was apparently controlled by the growth rate.
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